تفاعل #959840

معادلة التفاعل

Sodium triacetoxy borohydride

NaHCO3

Methyl 2-aminothiazole-4-carboxylate

3-hydroxy-2-butanone

acetic acid

Sodium triacetoxy borohydride

→

title product

المردود 68.1%

Methyl 2-(3-hydroxybutan-2-ylamino)thiazole-4-carboxylate

المردود 68.1%

المذيبات

1,2-dichloroethane

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe reaction mixture was stirred over two nights
2. 2
   استخلاصmixture was extracted twice with DCM
3. 3
   تجفيفDCM phase was dried
4. 4
   أخرىevaporated

الإجراء التجريبي

Methyl 2-aminothiazole-4-carboxylate (1.0, 6.32 mmol), 3-hydroxy-2-butanone (1.045 ml, 12.01 mmol) and acetic acid (2.278 g, 37.9 mmol) were dissolved in 1,2-dichloroethane. Sodium triacetoxy borohydride (3.75 g, 17.70 mmol) was added and the reaction mixture was stirred overnight. Sodium triacetoxy borohydride (3.1 g) was added in two portions and the reaction mixture was stirred over two nights. 1M NaHCO3 was added slowly and mixture was extracted twice with DCM. DCM phase was dried and evaporated to afford 68.1% of the title product. m/z [230.3+1].

المصدر