تفاعل #95984

معادلة التفاعل

S-methyl-isothiourea

chloroformic acid benzyl ester

sodium hydroxide

→

Benzyloxycarbonyl-S-methyl-isothiourea

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled to a temperature of 0° to 5° C.
2. 2
   workup.ADDITIONare added in about 20 minutes
3. 3
   أخرىThe precipitate formed
4. 4
   ترشيحis filtered
5. 5
   غسيلwashed three times with 50 ml of cold water
6. 6
   تجفيفthree times with 50 ml of n-hexane, and finally dried over phosphorpentoxide in vacuo

الإجراء التجريبي

13.9 g (0.1 mole) of S-methyl-isothiourea are dissolved in 50 ml of water, cooled to a temperature of 0° to 5° C., and at this temperature and with constant stirring 15 ml (0.1 mole) of chloroformic acid benzyl ester and 50 ml of 4 N sodium hydroxide are added in about 20 minutes. The precipitate formed is filtered, washed three times with 50 ml of cold water, then three times with 50 ml of n-hexane, and finally dried over phosphorpentoxide in vacuo. Yield 15.7 g (70 percent) of the named compound. M.p.: 74° to 75° C.; RF1 0.70 to 0.75.

المصدر