تفاعل #9571

معادلة التفاعل

5-bromo-N4-(2-methylpropyl)quinoline-3,4-diamine

triethyl orthoformate

pyridine hydrochloride

→

9-bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux overnight
3. 3
   تركيزThe reaction mixture was concentrated under reduced pressure
4. 4
   أخرىthe residue was purified by HPFC (
5. 5
   غسيلeluting with chloroform

الإجراء التجريبي

A mixture of 5-bromo-N4-(2-methylpropyl)quinoline-3,4-diamine (1.0 g, 3.4 mmol), triethyl orthoformate (0.9 mL, 5 mmol), and pyridine hydrochloride (117 mg, 1.0 mmol) in acetonitrile (17 mL) was heated at reflux overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by HPFC (eluting with chloroform:CMA in a gradient from 100:0 to 70:30) to provide 9-bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline as a dark oil.

المصدر