تفاعل #9568

معادلة التفاعل

ammonium hydroxide

1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine

nitric acid

→

1-(2-methylpropyl)-8-nitro-1H-imidazo[4,5-c]quinolin-4-amine

المذيبات

sulfuric acid

sulfuric acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction temperature was maintained below 10° C
2. 2
   أخرىA precipitate formed
3. 3
   أخرىwas isolated by filtration
4. 4
   غسيلwashed with water
5. 5
   أخرىdried

الإجراء التجريبي

A solution of 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine (28.3 g, 0.118 mol) in concentrated sulfuric acid (150 mL) was cooled to 5° C. A solution of 70% nitric acid (8.4 mL, 0.130 mol) in sulfuric acid (30 mL) was added in portions over a period of one hour. The reaction temperature was maintained below 10° C. The solution was allowed to warm to ambient temperature, stirred for two hours, and then poured into 500 g of ice. The resulting solution was made basic with the addition of ammonium hydroxide while keeping the solution cold. A precipitate formed, was isolated by filtration, washed with water, and dried to provide 1-(2-methylpropyl)-8-nitro-1H-imidazo[4,5-c]quinolin-4-amine as a yellow solid.

المصدر