تفاعل #955964

معادلة التفاعل

1,3-Dibromo-5-(heptadecan-9-yl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione

ethanol

acetic acid

HCl

→

1-bromo-5-(heptadecan-9-yl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione

المذيبات

CHCl3

hexane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةMixture was refluxed for one hour after which an aliquot
2. 2
   أخرىreaction
3. 3
   درجة الحرارةAfter cooling
4. 4
   ترشيحthe solution was filtered through fritted glass
5. 5
   أخرىwas evaporated under vacuum
6. 6
   أخرىProduct was obtained by silica chromatography

الإجراء التجريبي

1,3-Dibromo-5-(heptadecan-9-yl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione (9.43 g, 20.04 mmol) and zinc (1.31 g, 20.04 mmol) were placed in a 3 neck round-bottom flask equipped with a water condenser with ethanol (130 mL), acetic acid (40 mL) and 1 M HCl (2.5 mL). Mixture was refluxed for one hour after which an aliquot was taken for NMR analysis, which indicated reaction was complete. After cooling, the solution was filtered through fritted glass to eliminate remaining Zn particles and solvent was evaporated under vacuum. Product was obtained by silica chromatography, using a 100% hexane to 100% CHCl3 gradient.

المصدر