تفاعل #955938

معادلة التفاعل

4-chloro-2-methoxybenzoic acid

MeOH

→

methyl 4-chloro-2-methoxybenzoate

المردود 96.0%

المذيبات

H2SO4

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed overnight
2. 2
   أخرىMeOH was evaporated
3. 3
   استخلاصthe residue was extracted to EtOAc
4. 4
   غسيلsuccessively washed with water and brine
5. 5
   تجفيفdried over MgSO4
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated

الإجراء التجريبي

A suspension of 4-chloro-2-methoxybenzoic acid (5 g, 27 mmol) in MeOH (18 mL) and conc. H2SO4 (1.5 mL) was refluxed overnight. MeOH was evaporated and the residue was extracted to EtOAc and successively washed with water and brine, dried over MgSO4, filtered and evaporated to give methyl 4-chloro-2-methoxybenzoate as a white solid (5.17 g, 96%).

المصدر