تفاعل #955937

معادلة التفاعل

EtMgBr

methyl 4-chloro-2-methoxybenzoate

→

methyl 4-ethyl-2-methoxybenzoate

المردود 50.0%

المذيبات

THF

NMP

ether

ظروف التفاعل

المعالجة

1. 1
   أخرىgiving a red color
2. 2
   أخرىquenched upon the addition of aq. HCl (1M, 50 mL)
3. 3
   استخلاصThe crude product was extracted with ether
4. 4
   غسيلthe combined organic layers were successively washed with water and brine
5. 5
   تجفيفdried over MgSO4
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated
8. 8
   أخرىThe residue was purified on silica gel (Eluent: 30% EtOAc in hexanes)

الإجراء التجريبي

To a solution of methyl 4-chloro-2-methoxybenzoate (example 18d) (4.16 g, 20.8 mmol) in THF (120 mL) and NMP (12 mL) was added under inert atmosphere Iron (III) acetylacetonate (398 mg, 1.17 mmol) giving a red color. Then EtMgBr (29 ml of 1M solution in ether) was added dropwise under vigorous stirring. The mixture turned dark brown and then violet and then was stirred for 15 more min. The reaction was diluted with ether and quenched upon the addition of aq. HCl (1M, 50 mL). The crude product was extracted with ether and the combined organic layers were successively washed with water and brine, dried over MgSO4, filtered and evaporated. The residue was purified on silica gel (Eluent: 30% EtOAc in hexanes) to give methyl 4-ethyl-2-methoxybenzoate (2.01 g, 50%) as an oil. 1H NMR (300 MHz, dMSO): δ 1.20-1.22(t, 3H), 2.65-2.7 (dd, 2H), 3.9 (s, 3H), 6.8 (s, 1H), 6.97 (m, 1H), 7.7 (m, 1H).

المصدر