تفاعل #955448

معادلة التفاعل

2-chloro-6-fluoro-3-nitrotoluene

isopropanol

→

2-chloro-4-fluoro-3-methylaniline

المردود 61.1%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhole heated
2. 2
   ترشيحThe cooled mixture was then filtered
3. 3
   أخرىthe filtrate evaporated under reduced pressure
4. 4
   أخرىgiving an oil which
5. 5
   workup.DISTILLATIONon distillation

الإجراء التجريبي

To a mixture of 2-chloro-6-fluoro-3-nitrotoluene (140 g), isopropanol (560 ml) and water (147 ml), hydrogen reduced iron (172.2 g) was added hydrochloric acid (43 drops) and with vigorous stirring the whole heated to reflux temperature (82° C.) for 4 hours. The cooled mixture was then filtered and the filtrate evaporated under reduced pressure giving an oil which on distillation gave 2-chloro-4-fluoro-3-methylaniline (72 g).

المصدر