تفاعل #9554

معادلة التفاعل

1-amino-2-methylpropan-2-ol

7-benzyl-4-chloro-3-nitroquinoline

6-benzyl-4-chloro-3-nitroquinoline

triethylamine

→

1-(7-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

1-(6-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe volatiles were removed under reduced pressure
2. 2
   workup.STIRRINGthe residue was stirred with water (50 mL) for one hour
3. 3
   أخرىThe resulting yellow solid was isolated by filtration
4. 4
   غسيلwashed with water

الإجراء التجريبي

Under a nitrogen atmosphere, 1-amino-2-methylpropan-2-ol (1.2 equivalents) was added to a 0.2 M solution of 7-benzyl-4-chloro-3-nitroquinoline or 6-benzyl-4-chloro-3-nitroquinoline (1 equivalent) and triethylamine (3 equivalents) in dichloromethane, and the reaction was stirred overnight at ambient temperature. The volatiles were removed under reduced pressure, and the residue was stirred with water (50 mL) for one hour. The resulting yellow solid was isolated by filtration and washed with water to provide 1-(7-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol or 1-(6-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol, respectively.

المصدر