تفاعل #9550

معادلة التفاعل

1-(2-methylpropyl)-7-styryl-1H-imidazo[4,5-c]quinolin-4-amine

→

1-(2-methylpropyl)-7-phenethyl-1H-imidazo[4,5-c]quinolin-4-amine

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe crude product was purified by flash column chromatography on silica gel (eluting with 90:10 chloroform:CMA)
2. 2
   أخرىfollowed by recrystallization from acetonitrile

الإجراء التجريبي

A modification of the method described in Example 123 was used to reduce 1-(2-methylpropyl)-7-styryl-1H-imidazo[4,5-c]quinolin-4-amine (1.2 g, 3.5 mmol). The reaction was carried out in methanol (100 mL) for seven days. The crude product was purified by flash column chromatography on silica gel (eluting with 90:10 chloroform:CMA) followed by recrystallization from acetonitrile to provide 1-(2-methylpropyl)-7-phenethyl-1H-imidazo[4,5-c]quinolin-4-amine as white crystals, mp 172–173° C.

المصدر