تفاعل #9544

معادلة التفاعل

1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine

N-bromosuccinimide

→

8-bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]-quinolin-4-amine

المردود 22.6%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe resulting dark red solution was heated
2. 2
   درجة الحرارةat reflux for 45 minutes
3. 3
   أخرىA precipitate formed
4. 4
   أخرىwas isolated by filtration
5. 5
   غسيلwas washed with water and diethyl ether

الإجراء التجريبي

A solution of 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine (30.0 g, 125 mmol) in chloroform (620 mL) was heated to 50° C., and N-bromosuccinimide (28.8 g, 162 mmol) was added in five portions over a period of five minutes. The resulting dark red solution was heated at reflux for 45 minutes, allowed to cool to ambient temperature, and stirred for one hour. A precipitate formed, was isolated by filtration, and was washed with water and diethyl ether to provide 9.0 g of 8-bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]-quinolin-4-amine as a solid.

المصدر