تفاعل #95438

معادلة التفاعل

sodium hydroxide

3,6-dichloropyridazine

meta-aminophenol

→

3-(6-chloro-3-pyridazinyloxy)benzeneamine

المذيبات

dimethyl sulfoxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe stirred mixture was heated
2. 2
   درجة الحرارةrefluxed (150°-155° C.) for two hours
3. 3
   درجة الحرارةcooled
4. 4
   ترشيحfiltered
5. 5
   أخرىThe filter cake was recrystallized from aqueous methanol

الإجراء التجريبي

A concentrated aqueous solution of 44 g of sodium hydroxide was added to a stirred solution of 149 g of 3,6-dichloropyridazine and 114.5 g of meta-aminophenol in 500 ml of dimethyl sulfoxide, at room temperature. The stirred mixture was heated, refluxed (150°-155° C.) for two hours, cooled, and filtered. The filter cake was recrystallized from aqueous methanol to give 3-(6-chloro-3-pyridazinyloxy)benzeneamine (1A), as an off-white solid, mp: 76°-77° C.

المصدر