تفاعل #95331

ord-e41a7caf7c83446eabe7ce3a36ff9a8f

معادلة التفاعل

CCC[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CC[C@H]4CC(=O)C[C@H](C)[C@]4(C)[C@H]3CC[C@@]21C
17β-acetoxy-1α-methyl-17α-n-propyl-5α-androstan-3-one
CC(C)(C)[O][Al]([O]C(C)(C)C)[O]C(C)(C)C.[H-].[Li+]
lithium tri-tert.-butoxyaluminum hydride
→
CCC[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)C[C@H](C)[C@]4(C)[C@H]3CC[C@@]21C
17β-acetoxy-1α-methyl-17α-n-propyl-5α-androstan-3β-ol
المردود 64.7%

المتفاعلات

CCC[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CC[C@H]4CC(=O)C[C@H](C)[C@]4(C)[C@H]3CC[C@@]21C
17β-acetoxy-1α-methyl-17α-n-propyl-5α-androstan-3-one
CC(C)(C)[O][Al]([O]C(C)(C)C)[O]C(C)(C)C.[H-].[Li+]
lithium tri-tert.-butoxyaluminum hydride

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

1.0 g of 17β-acetoxy-1α-methyl-17α-n-propyl-5α-androstan-3-one is reacted as described in Example 6 with lithium tri-tert.-butoxyaluminum hydride and worked up. After chromatography on silica gel, 650 mg of 17β-acetoxy-1α-methyl-17α-n-propyl-5α-androstan-3β-ol is obtained as an oil.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04344941uspto-grants-1982_08