تفاعل #95276

معادلة التفاعل

sodium iodide

1-chloro-trans-1-octen 3-one

1-chloro-trans-1-octen-3-one

→

1-iodo-trans-1-octen-3-one

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONA mixture of 54.5 g
2. 2
   درجة الحرارةrefluxed for 24 hours
3. 3
   درجة الحرارةThe reaction mixture is cooled
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated
6. 6
   أخرىThe residue is partitioned between water and ether
7. 7
   غسيلThe organic phase is washed with dilute sodium bicarbonate solution, brine
8. 8
   تجفيفdried (MgSO4)
9. 9
   أخرىevaporated to an oil
10. 10
    أخرىThis material is used directly without purification

الإجراء التجريبي

A mixture of 54.5 g. (0.364 mole) of sodium iodide and 40 g. (0.249 mole) of 1-chloro-trans-1-octen 3-one (Example 723) in 360 ml. of acetone is stirred and refluxed for 24 hours. The reaction mixture is cooled, filtered and concentrated. The residue is partitioned between water and ether. The organic phase is washed with dilute sodium bicarbonate solution, brine, dried (MgSO4) and evaporated to an oil. This material is used directly without purification.

المصدر