تفاعل #95223

معادلة التفاعل

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2,4-dichlorobenzoyl chloride

→

pure product

المردود 69.5%

5-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

المردود 69.5%

المذيبات

xylene

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated in vacuo
2. 2
   استخلاصthe resulting residue extracted with benzene
3. 3
   workup.ADDITIONAddition of hexane

الإجراء التجريبي

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.9 g (0.10 mole) 2,4-dichlorobenzoyl chloride was refluxed in 200 ml xylene for 20 hours. The reaction mixture was concentrated in vacuo and the resulting residue extracted with benzene. Addition of hexane resulted in precipitation of 13.6 g (69% yield) pure product; m.p. 136° C.

المصدر