تفاعل #95222

معادلة التفاعل

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2,6-dichlorobenzoyl chloride

→

pure product

المردود 22.0%

5-(2,6-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

المردود 22.0%

المذيبات

dichlorobenzene

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter filtration
2. 2
   أخرىthe crude product precipitated from the filtrate
3. 3
   أخرىRecrystallization from toluene

الإجراء التجريبي

A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.1 g (0.1 mole) 2,6-dichlorobenzoyl chloride was refluxed for 8 hours in 200 ml dichlorobenzene. After filtration, the crude product precipitated from the filtrate upon standing. Recrystallization from toluene gave 8.6 g (22% yield) of pure product; m.p. 209° C.

المصدر