تفاعل #95189

معادلة التفاعل

2-[3-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5yloxy]-2-methyl-propanoic acid

piperidine

→

2-[3-(4-Chlorophenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methyl-propanoic acid piperidide

المذيبات

tetrahydrofurane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was refluxed for 12 hours
2. 2
   أخرىAfter evaporation the residue
3. 3
   workup.ADDITIONwas mixed with dilute hydrochloric acid
4. 4
   استخلاصextracted with ether
5. 5
   أخرىThe evaporated ether residue was purified by column chromatography with toluene/ethyl acetate (8:2) on silicagel

الإجراء التجريبي

An amount of 0.5 g (1.4 m mole) of 2-[3-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5yloxy]-2-methyl-propanoic acid was dissolved in 25 ml of tetrahydrofurane and heated for four hours with 0.24 g (1.4 m mole) of N,N'-carbonyldiimidazole on a steam bath. Subsequently, 0.24 g (2.8 m mole) of piperidine were added, and the mixture was refluxed for 12 hours. After evaporation the residue was mixed with dilute hydrochloric acid and extracted with ether. The evaporated ether residue was purified by column chromatography with toluene/ethyl acetate (8:2) on silicagel.

المصدر