تفاعل #95100

معادلة التفاعل

2-bromo-propiophenone

4-benzyloxy-aniline

→

5Benzyloxy-3-methyl-2-phenyl-1H-indole

المذيبات

triethylamine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was evaporated to dryness
2. 2
   درجة الحرارةthe residue was heated for two hours to 180° C
3. 3
   درجة الحرارةAfter cooling
4. 4
   workup.ADDITIONthe residue was mixed with 10% hydrochloric acid
5. 5
   استخلاصextracted with chloroform
6. 6
   تجفيفThe extracts were dried over sodium sulfate
7. 7
   ترشيحfiltered
8. 8
   أخرىevaporated
9. 9
   أخرىThe residue obtained
10. 10
    أخرىwas purified by column chromatography on silicagel with toluene as solvent

الإجراء التجريبي

An amount of 3.6 g (0.015 mole) of 2-bromo-propiophenone and 6 g (0.03 mole) of 4-benzyloxy-aniline were refluxed for two hours in 15 ml of triethylamine. The mixture was evaporated to dryness, and the residue was heated for two hours to 180° C. After cooling, the residue was mixed with 10% hydrochloric acid and extracted with chloroform. The extracts were dried over sodium sulfate, filtered, and evaporated. The residue obtained was purified by column chromatography on silicagel with toluene as solvent.

المصدر