تفاعل #949030

معادلة التفاعل

Compound 402

4-Ethyl-4-(tetrahydro-4H-pyran-2-yloxy)-1-(4 -toluensulfonyloxy)hex-2-yne

sodium bromide

Ether

→

title compound

المردود 73.3%

1-Bromo-4-ethyl-4-(tetrahydro-4H-pyran-2-yloxy)hex-2-yne

المردود 73.3%

المذيبات

DMF

ether pentane

ظروف التفاعل

الإجراء التجريبي

A mixture of Compound 402 (7.0 g) and sodium bromide (7.0 g) in DMF (50 ml) was stirred at r.t. for 4 h. Ether (300 ml) was added and the mixture was worked up with chromatography with ether/pentane 1:1 (v/v) as eluent to give the title compound (3.9 g). 1H NMR: 0.96 (t, 3H), 0.96 (t, 3H) 1.45-1.90 (m, 10E), 3.51 (m, 1H), 3.95 (m, 1H), 3.98 (s, 2H), 5.00 (m, 1H).

المصدر