تفاعل #94831

معادلة التفاعل

6-propyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

n-butyl bromide

potassium hydroxide

→

3-n-butyl-6-propyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 48 hours
2. 2
   أخرىThe reaction mixture is evaporated to dryness
3. 3
   ترشيحfiltered
4. 4
   أخرىto remove inorganic salts
5. 5
   غسيلThe filtrate is washed with water
6. 6
   أخرىdried
7. 7
   أخرىevaporated

الإجراء التجريبي

A mixture of 4.5 g of 6-propyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 0.02 mole of n-butyl bromide and 0.02 mole of potassium hydroxide is dissolved in 120 ml of dry methanol and refluxed for 48 hours. The reaction mixture is evaporated to dryness, taken up in ethyl acetate and filtered to remove inorganic salts. The filtrate is washed with water, dried and evaporated to give 3-n-butyl-6-propyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

المصدر