تفاعل #94819

ord-d5519e15d0b24fb0a5ede94dfa48bb1f

معادلة التفاعل

Cn1cc(C(=O)C=CC(=O)O)cn1
3-(1-methyl-4-pyrazolylcarbonyl)acrylic acid
O=C(O)[C@@H]1CCCN1
L-proline
Cn1cc(C(=O)C=CC(=O)N2CCC[C@H]2C(=O)O)cn1
1-[3-(1-methyl-4-pyrazolylcarbonyl)acryloyl]-L-proline
CC(O)=S
thioacetic acid
→
CC(=O)SC(CC(=O)c1cnn(C)c1)C(=O)N1CCC[C@H]1C(=O)O
1-[2-Acetylthio-3-(1-methyl-4-pyrazolylcarbonyl)-propionyl]-L-proline

المتفاعلات

Cn1cc(C(=O)C=CC(=O)O)cn1
3-(1-methyl-4-pyrazolylcarbonyl)acrylic acid
O=C(O)[C@@H]1CCCN1
L-proline
Cn1cc(C(=O)C=CC(=O)N2CCC[C@H]2C(=O)O)cn1
1-[3-(1-methyl-4-pyrazolylcarbonyl)acryloyl]-L-proline
CC(O)=S
thioacetic acid

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىto give the product of the Example as a glass

الإجراء التجريبي

As for Example 29, 3-(1-methyl-4-pyrazolylcarbonyl)acrylic acid is coupled to L-proline and the resulting 1-[3-(1-methyl-4-pyrazolylcarbonyl)acryloyl]-L-proline is reacted with thioacetic acid to give the product of the Example as a glass.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04342691uspto-grants-1982_08