تفاعل #94730

معادلة التفاعل

ethyl 3,3-dimethyl-5-phenylthiopentanoate

1-chloro-2,5-pyrrolidinedione

→

ethyl 5-chloro-3,3-dimethyl-5-phenylthiopentanoate

المذيبات

carbon tetrachloride

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered
2. 2
   تركيزthe filtrate concentrated

الإجراء التجريبي

To a solution of 1.06 g (3.09 mmol) of ethyl 3,3-dimethyl-5-phenylthiopentanoate in 10 mL of carbon tetrachloride was added 590 mg (4.4 mmol) of 1-chloro-2,5-pyrrolidinedione, and the mixture was stirred at room temperature for 2 hours. The mixture was filtered, and the filtrate concentrated to give ethyl 5-chloro-3,3-dimethyl-5-phenylthiopentanoate as an oil. The product was used without further purification in the reaction described in Example 3 below. NMR Data (CDCl3):

المصدر