تفاعل #9473

معادلة التفاعل

1-(2-methylpropyl)-8-styryl-1H-imidazo[4,5-c]quinolin-4-amine

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1-(2-methylpropyl)-8-phenethyl-1H-imidazo[4,5-c]quinolin-4-amine

المردود 21.8%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىfor six days
2. 2
   ترشيحThe reaction mixture was filtered through a layer of CELITE
3. 3
   ترشيحfilter aid
4. 4
   غسيلthe filter cake was washed with ethanol
5. 5
   تركيزThe filtrate was concentrated under reduced pressure
6. 6
   أخرىthe residue was recrystallized from methanol

الإجراء التجريبي

A solution of 1-(2-methylpropyl)-8-styryl-1H-imidazo[4,5-c]quinolin-4-amine (1.37 g, 4.00 mmol) in ethanol (40 mL) was added to a Parr vessel charged with 10% palladium on carbon (137 mg). The reaction was placed under hydrogen pressure (40 psi, 2.8×105 Pa) for six days. The reaction mixture was filtered through a layer of CELITE filter aid, and the filter cake was washed with ethanol. The filtrate was concentrated under reduced pressure, and the residue was recrystallized from methanol to provide 0.300 g of 1-(2-methylpropyl)-8-phenethyl-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, mp 175–178° C.

المصدر