تفاعل #94722

معادلة التفاعل

2-amino-4,5,6-trimethylpyrimidine

methylene chloride

methyl 2-(isocyanatosulfonyl)benzoate

→

Methyl 2-{[(4,5,6-trimethylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl}benzoate

المذيبات

Butyl chloride

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGwith constant stirring
2. 2
   ترشيحthe insoluble product filtered
3. 3
   غسيلwashed immediately with butyl chloride
4. 4
   أخرىdried

الإجراء التجريبي

To a mixture of 1.0 gram (0.0073 mole) of 2-amino-4,5,6-trimethylpyrimidine and 5.0 ml of dried methylene chloride stirring magnetically in a 50 ml RB single neck flask, 2.1 grams of methyl 2-(isocyanatosulfonyl)benzoate was added at room temperature and the mixture stirred at room temperature for 24 hours. Butyl chloride (4 ml) was added with constant stirring and the insoluble product filtered, washed immediately with butyl chloride and dried. (Yield 1.3 grams, m.p. 152°-161°). IR (Nujol): 5.60, 5.75 (C=O), 11.25 11.90 microns; NMR (TFA-d): δ2.30 (s,3H,CH3), 2.65 (s, 6H, 2CH3), 4.00 (s, 3H, CO2CH3), 7.60-8.60 (m, ArH).

المصدر