تفاعل #9465

معادلة التفاعل

8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

2,4-dimethoxybenzeneboronic acid

→

8-(2,4-dimethoxyphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

ظروف التفاعل

المعالجة

1. 1
   أخرىPurification by chromatography on silica gel (7% methanol in CH2Cl2)

الإجراء التجريبي

8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and 2,4-dimethoxybenzeneboronic acid were coupled according to the general procedure described in Part J of Example 1. Purification by chromatography on silica gel (7% methanol in CH2Cl2) afforded 8-(2,4-dimethoxyphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. 223–227° C.

المصدر