تفاعل #946

معادلة التفاعل

NaOH

product

(+-)-Ethyl 2-amino-2-ethylhex-4-enoate

lithium aluminium hydride

→

desired product

المردود 32.5%

(+-)-2-Amino-2-ethylhex-4-en-1-ol

المردود 32.5%

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONWhen addition
2. 2
   أخرىThe organic phase was separated
3. 3
   غسيلwashed with brine
4. 4
   أخرىdried
5. 5
   أخرىevaporated in vacuo
6. 6
   workup.DISTILLATIONThe residue was distilled

الإجراء التجريبي

A solution of the product from step (d) (116.7 g) in THF (100 ml) was added to a 1M solution of lithium aluminium hydride in THF (800 ml) at about 0° C. When addition was complete, the mixture was stirred overnight at room temperature, then 50% w/v aqu. NaOH (200 ml) was added. The organic phase was separated, washed with brine, dried and evaporated in vacuo. The residue was distilled to give the desired product as an oil (29.3 g). 1H NMR consistent with the proposed structure.

المصدر