تفاعل #94511

معادلة التفاعل

end product

8-Chloro-6-phenyl-4H-pyrazolo[1,5-a][1,4]benzodiazepine-2-carboxylic acid, methyl ester

dimethylamine

→

8-Chloro-N,N-dimethyl-6-phenyl-4H-pyrazolo[1,5-a][1,4]benzodiazepine-2-carboxamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThis compound was prepared from 700 mg
2. 2
   درجة الحرارةThe reaction mixture was heated to 60°-65° in a sealed glass bomb for 16 hours
3. 3
   أخرىRecrystallization from acetone/ether/hexane
4. 4
   أخرىyielded the desired end product

الإجراء التجريبي

This compound was prepared from 700 mg. (1.99 mmol) of the end product of Example 9 and dimethylamine according to a procedure similar to that described above in Example 11. The reaction mixture was heated to 60°-65° in a sealed glass bomb for 16 hours. Recrystallization from acetone/ether/hexane yielded the desired end product: mp 176°-178°.

المصدر