تفاعل #945

معادلة التفاعل

benzaldehyde

product

Ethyl 2-aminobutyrate hydrochloride

magnesium sulphate

triethylamine

→

desired product

المردود 88.9%

Ethyl 2-benzylideneaminobutyrate

المردود 88.9%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحthen filtered
2. 2
   تركيزThe filtrate was concentrated
3. 3
   أخرىtriturated in diethyl ether
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated

الإجراء التجريبي

A solution of the product from step (a) (149.6 g), magnesium sulphate (74.3 g), and triethylamine (246 ml) in dichloromethane (1500 ml) was stirred at room temperature under nitrogen and benzaldehyde (94.9 g, Aldrich) was added dropwise. The mixture was stirred at room temperature for 3 hours then filtered. The filtrate was concentrated, triturated in diethyl ether, filtered and concentrated to yield the desired product as a yellow oil (174 g). 1H NMR consistent with the proposed structure.

المصدر