تفاعل #944584

ord-5c1f354b33854899b8b2c11389104563

معادلة التفاعل

O=C(Cl)c1ccc(Cl)cc1I
4-chloro-2-iodobenzoyl chloride
COC(=O)C[C@H]1CCn2c1cc1c(C(C)C)cc(F)cc12
methyl[(1R)-6-fluoro-8-isopropyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate
→
CC(C)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1I)c1n2CC[C@@H]1CC(=O)O
title compound
CC(C)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1I)c1n2CC[C@@H]1CC(=O)O
[(1R)-9-(4-CHLORO-2-IODOBENZOYL)-6-FLUORO-8-ISOPROPYL-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-yl]ACETIC ACID

المتفاعلات

O=C(Cl)c1ccc(Cl)cc1I
4-chloro-2-iodobenzoyl chloride
COC(=O)C[C@H]1CCn2c1cc1c(C(C)C)cc(F)cc12
methyl[(1R)-6-fluoro-8-isopropyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Starting from 4-chloro-2-iodobenzoyl chloride (542 mg, 1.8 mmol) and methyl[(1R)-6-fluoro-8-isopropyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 44A, Step 1, 173 mg, 0.6 mmol), the title compound was synthesized following the procedures described in Step 1 of Example 61 and Step 10 of Example 7.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07144913B2uspto-grants-2006_12