تفاعل #944256

معادلة التفاعل

2-(4-aminophenyl)-6-methylbenzothiazole

para-toluenesulphonyl chloride

water

→

N-[4-(6-methylbenzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide

المذيبات

pyridine

pyridine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was heated
2. 2
   درجة الحرارةat reflux for 10 mins
3. 3
   درجة الحرارةcooled
4. 4
   أخرىThe white precipitate formed
5. 5
   أخرىwas collected on a filter
6. 6
   غسيلwashed with water
7. 7
   أخرىdried under vacuum

الإجراء التجريبي

To 2-(4-aminophenyl)-6-methylbenzothiazole (5 g, 20.8 mmol) in pyridine (60 mL) was added para-toluenesulphonyl chloride (5.953 g, 31.2 mmol, 1.5 eq.) in pyridine (40 mL). The reaction mixture was heated at reflux for 10 mins, then cooled and water (100 mL) added. The white precipitate formed was collected on a filter, washed with water and dried under vacuum to give N-[4-(6-methylbenzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide as a white solid. The yield was 8.091 g (99%).

المصدر