تفاعل #943989

معادلة التفاعل

water

7-hydroxy-6-methoxy-1-tetralone

benzyl bromide

K2CO3

→

product

المردود 62.8%

7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one

المردود 62.8%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةto reflux overnight
3. 3
   أخرىThe reaction
4. 4
   درجة الحرارةas cooled
5. 5
   استخلاصextracted with EtOAc
6. 6
   تجفيفThe EtOAc was dried over Na2SO4
7. 7
   أخرىevaporated
8. 8
   أخرىto give 7 g of crude product
9. 9
   أخرىCrystallization with Et2O

الإجراء التجريبي

A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.

المصدر