تفاعل #94343

معادلة التفاعل

2-(4-methyl-5-thiazolyl)-ethyl-mercaptan

dimethyldisulphide

→

[2-(4-methyl-5-thiazolyl)-ethyl]-methyl-disulphide

المردود 60.4%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture is heated
2. 2
   درجة الحرارةto reflux for 4 hours
3. 3
   workup.WAITThe mixture is then left
4. 4
   درجة الحرارةto cool
5. 5
   ترشيحfiltered over 10 g of aluminium oxide (activity I, neutral), which
6. 6
   غسيلis back-washed with ether
7. 7
   تركيزconcentrated in a vacuum
8. 8
   workup.DISTILLATIONThe resulting crude product (9.5 g) is distilled through a Hempel column under a high vacuum

الإجراء التجريبي

A mixture of 8.26 g (0.052 mol) of 2-(4-methyl-5-thiazolyl)-ethyl-mercaptan and 33.07 g (0.208 mol) of dimethyldisulphide is treated with 50 mg of sodium hydride (50% dispersion in oil) and the mixture is heated to reflux for 4 hours. The mixture is then left to cool, filtered over 10 g of aluminium oxide (activity I, neutral), which is back-washed with ether, and concentrated in a vacuum. The resulting crude product (9.5 g) is distilled through a Hempel column under a high vacuum, there being obtained 6.45 g of [2-(4-methyl-5-thiazolyl)-ethyl]-methyl-disulphide. Boiling point 104°-110°/0.02 mm Hg; nD20 = 1.5944; purity: 99%. IR (liq.): bands inter alia at 3100, 2960, 1545, 1415, 1220, 955, 1005, 840, 795 cm-1.

المصدر