تفاعل #93956
ord-6b95a365086e4e3fa90b5593564ad1c0
معادلة التفاعل
isatin
isatin
p-toluenesulfonylhydrazine
sodium hydroxide
aluminum oxide
→
3-diazoindol-2(3H)-one
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىthe corresponding 3-diazoindol-2(3H)-one is prepared in accordance with known procedures
الإجراء التجريبي
Once the desired isatin has been obtained, the corresponding 3-diazoindol-2(3H)-one is prepared in accordance with known procedures. See, for example, J. M. Michowski, Tetrahedron Letters, 1773 (1967) and M. P. Cava, et al., J. Am. Chem. Soc., 80, 2257 (1958). The appropriate isatin compound is treated with p-toluenesulfonylhydrazine. The resulting hydrazone then is treated with a base such as aqueous sodium hydroxide or aluminum oxide to give the desired 3-diazoindol-2(3H)-one.