تفاعل #93918

معادلة التفاعل

acetic acid

ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

hydrogen peroxide

water

→

title compound

8-vinylsulfonyl-12-hydroxyheptadecanoic acid

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe solution is diluted with 600 ml
2. 2
   غسيلwashed with dilute sodium bicarbonate solution and four portions of water
3. 3
   تجفيفdried over sodium sulfate
4. 4
   أخرىEvaporation of the ether in vacuo

الإجراء التجريبي

A solution of ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate (45.1 g., 0.1 mole) and 30% aqueous hydrogen peroxide (50 ml.) in acetic acid (225 ml.) is allowed to stand 20 hours at 25° C. The solution is diluted with 600 ml. of water. The oily product is taken up in ether, washed with dilute sodium bicarbonate solution and four portions of water and dried over sodium sulfate. Evaporation of the ether in vacuo leaves the title compound as a light yellow viscous oil.

المصدر