تفاعل #939044

معادلة التفاعل

4-isobutoxy-3-nitrobenzoyl chloride

4,5,6-triaminopyrimidine sulfate

Water

→

desired compound

المردود 21.0%

6-Amino-8-(4-isobutoxy-3-nitrophenyl)purine

المردود 21.0%

المذيبات

1,4-dioxane

sodium hydroxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder cooling with ice
2. 2
   ترشيحThe precipitated solid product was collected by filtration
3. 3
   أخرىdried in air

الإجراء التجريبي

A solution of 4-isobutoxy-3-nitrobenzoyl chloride (538 mg, 2.09 mmol) in 1,4-dioxane (2 mL) was dropwise added to a suspension of 4,5,6-triaminopyrimidine sulfate (466 mg, 2.09 mmol) in aqueous 1M sodium hydroxide (4.18 30 mL) under cooling with ice. The resulting mixture was stirred for 4 hours at the same temperature. Water (12 mL) was added to the reaction mixture. The precipitated solid product was collected by filtration, dried in air, and subjected to silica gel column chromatography. The elute using chloroform/methanol (10/1) gave 144 mg (yield 20%) of the desired compound in the form of a yellow powdery product.

المصدر