تفاعل #938707

معادلة التفاعل

acetonylacetone

3,6-dichloropyridazine

methylhydrazine

sodium bicarbonate

hydrochloric acid

→

6-chloro-N-(2,5-dimethyl-1H-pyrrol-1-yl)-N-methyl-3-pyridazineamine

المردود 59.2%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis heated to the reflux temperature for two hours
2. 2
   أخرىthe obtained precipitate is collected
3. 3
   أخرىcrystallized from ethyl ether

الإجراء التجريبي

A mixture of water (300 ml), 3,6-dichloropyridazine (29.8 g; 0.2 mole), methylhydrazine (9.2 g; 0.2 mole), and sodium bicarbonate (17.8 g; 0.2 mole), is heated to the reflux temperature for two hours. After cooling to about 60° C., acetonylacetone (22.2 g; 0.2 mole) is added and stirring is prosecuted for further 1 hour. Then the mixture is neutralized with hydrochloric acid and the obtained precipitate is collected and crystallized from ethyl ether, yielding 28 g (59.2%) of 6-chloro-N-(2,5-dimethyl-1H-pyrrol-1-yl)-N-methyl-3-pyridazineamine, whose structure is confirmed by I.R. and NMR spectra. M.p. 93°-94.5° C.

المصدر