تفاعل #93855

معادلة التفاعل

2,2-dimethyl-1-ethinyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-naphthol

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2,2-Dimethyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-vinyl-1-naphthol

المردود 95.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىis submitted to hydrogenation at atmospheric pressure and room temperature
2. 2
   أخرىAfter the absorption of 1200 ml of hydrogen the catalysts
3. 3
   أخرىare removed by filtration
4. 4
   تركيزThe solution is concentrated by evaporation in vacuo of most of the solvent
5. 5
   أخرىwhereafter the product crystallizes as white crystals melting at 152°-154° C

الإجراء التجريبي

A mixture of 205 g of 2,2-dimethyl-1-ethinyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-naphthol, 0.8 g of 0,5% palladium on calcium carbonate, 0.8 g 5% palladium on charcoal and 1000 ml of ethyl acetate is submitted to hydrogenation at atmospheric pressure and room temperature. After the absorption of 1200 ml of hydrogen the catalysts are removed by filtration. The solution is concentrated by evaporation in vacuo of most of the solvent, whereafter the product crystallizes as white crystals melting at 152°-154° C. Yield 95%.

المصدر