تفاعل #93815

معادلة التفاعل

6-bromo-α-(3-phenoxyphenyl)-2-pyridinemethanol

acetic acid

→

6-bromo-2-(3-phenoxybenzoyl)-pyridine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىat room temperature
2. 2
   استخلاصwater and extracted with chloroform
3. 3
   غسيلThe organic layer is washed with 2.5N NaOH
4. 4
   تجفيفwith water, dried (Na2SO4) and solvent
5. 5
   أخرىremoved

الإجراء التجريبي

A solution of 5 g chromium trioxide in 10 ml water is added to a mixture of 20 g 6-bromo-α-(3-phenoxyphenyl)-2-pyridinemethanol (see Ex. 18) and 70 ml glacial acetic acid. After stirring for 1 hr. at room temperature, the reaction mixture is dded to ice:water and extracted with chloroform. The organic layer is washed with 2.5N NaOH, then with water, dried (Na2SO4) and solvent removed. Yield: 15.4 g of the title product, m.p. 65°-6° C. (from methanol); Br 22.87 (22.56).

المصدر