تفاعل #93728

معادلة التفاعل

tetrafluoroisophthalonitrile

acetonitrile

sodium bicarbonate

→

desired compound

المردود 61.0%

4-Amino-2,5,6-trifluoroisophthalonitrile

المردود 61.0%

المذيبات

ammonia

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter the dropwise addition
2. 2
   استخلاصthe resultant mixture was extracted with chloroform
3. 3
   غسيلwas washed with an aqueous sodium chloride solution
4. 4
   تجفيفAfter drying with sodium sulfate
5. 5
   workup.DISTILLATIONthe chloroform was distilled off
6. 6
   أخرىto obtain yellow crystal
7. 7
   أخرىThe resultant crystal was recrystallized from chloroform

الإجراء التجريبي

To a solution of 2.0 g of tetrafluoroisophthalonitrile in 20 ml of acetonitrile, 0.6 ml of 28% aqueous ammonia was dropwise added. After the dropwise addition, the mixture was stirred at room temperature for one hour. An aqueous sodium bicarbonate solution was added to the mixture and the resultant mixture was extracted with chloroform and was washed with an aqueous sodium chloride solution. After drying with sodium sulfate, the chloroform was distilled off to obtain yellow crystal. The resultant crystal was recrystallized from chloroform to obtain 1.2 g (61% yield) of the desired compound No. 1.

المصدر