تفاعل #93605

معادلة التفاعل

2-Chloro-α,α,α-trifluoro-p-tolyl-3-(1-carbethoxyethoxy)-4-nitrophenyl ether

potassium hydroxide

ethanol

sulfuric acid

→

2-chloro-α,α,α-trifluoro-p-tolyl-3-(1-carboxyethoxy)-4 -nitrophenyl ether

المردود 79.0%

المذيبات

water

dioxane

water

Ether

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe water layer extracted three times with ether (200 ml
2. 2
   أخرىeach) dried
3. 3
   أخرىthe ether removed

الإجراء التجريبي

2-Chloro-α,α,α-trifluoro-p-tolyl-3-(1-carbethoxyethoxy)-4-nitrophenyl ether (8.6 g. 0.02 mol), potassium hydroxide 86% (2.6 g. 0.04 mol), ethanol (8 ml.), dioxane (8 ml.), and water (100 ml.) are heated at 90°-95° C. for 30 minutes. Ether (200 ml.) and water (200 ml.) are added and the mixture acidified with dilute sulfuric acid, the water layer extracted three times with ether (200 ml. each) dried, and the ether removed to give 2-chloro-α,α,α-trifluoro-p-tolyl-3-(1-carboxyethoxy)-4 -nitrophenyl ether (6.4 g. 79%) m.p. 108°-109° C.

المصدر