تفاعل #9359

معادلة التفاعل

8-(2-Benzyloxy-ethyl)-1,4-dioxa-spiro[4.5]decane

H2O

TsOH

→

4-(2-benzyloxy-ethyl)-cyclohexanone

المردود 97.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter a standard aqueous work-up the material was purified by chromatography on SiO2

الإجراء التجريبي

8-(2-Benzyloxy-ethyl)-1,4-dioxa-spiro[4.5]decane (Intermediate K1, 1.02 g, 3.70 mmol) (prepared in accordance with the publication Ciufolini et. al. J. Amer. Chem. Soc. 1991, 113, 8016, incorporated herein by reference) was dissolved in acetone (100 mL): H2O (5 mL) and reacted with TsOH (140 mg, 0.74 mmol) at 45° C. for 5 h. After a standard aqueous work-up the material was purified by chromatography on SiO2 to give 4-(2-benzyloxy-ethyl)-cyclohexanone as a colorless oil (97%).

المصدر