تفاعل #9357

معادلة التفاعل

amide

N-(8-oxo-5,6,7,8-tetrahydro-naphthalen-1-yl)-acetamide

Na2CO3

NaOH

→

8-amino-3,4-dihydro-2H-naphthalen-1-one

المردود 56.0%

المذيبات

HCl

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe aqueous layer was extracted with EtOAc
2. 2
   غسيلwashed with brine
3. 3
   أخرىdried
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated

الإجراء التجريبي

The amide (Intermediate J2, 4.12 g, 20.3 mmol) was heated at 90° C. in 6N HCl (140 mL) for 3 h. The mixture was cooled to rt and Na2CO3 was added in small portions followed by addition of 2N NaOH until the mixture was at pH 8. The aqueous layer was extracted with EtOAc and the organic fractions were combined, washed with brine, dried, filtered and concentrated to give 8-amino-3,4-dihydro-2H-naphthalen-1-one (Intermediate J3) as a dark red solid 1.82 g (56%).

المصدر