تفاعل #93538

معادلة التفاعل

pyridine

α-mercaptomethyl-β-phenyl-γ-butyrolactone

p-n-butylbenzoyl chloride

→

title compound

المردود 79.1%

α-(p-n-butylbenzoylthiomethyl)-β-phenyl-γ-butyrolactone

المردود 79.1%

المذيبات

ethyl ether

ethyl ether

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion of the reaction
2. 2
   غسيلwashed with 10% hydrochloric acid, 10% aqueous sodium hydrogen carbonate
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   أخرىThe crude product thus obtained
6. 6
   أخرىwas purified by a silica gel column chromatography

الإجراء التجريبي

To a solution of 1.5 g of α-mercaptomethyl-β-phenyl-γ-butyrolactone in 30 ml of ethyl ether were added at room temperature 4.3 g of p-n-butylbenzoyl chloride and then 1.9 ml of pyridine. The mixture was kept at room temperature for 2.5 hours. After completion of the reaction, the reaction mixture was diluted with 100 ml of ethyl ether, washed with 10% hydrochloric acid, 10% aqueous sodium hydrogen carbonate and then satureated saline, dried over magnesium sulfate and the solvent was distilled off. The crude product thus obtained was purified by a silica gel column chromatography to give 2.1 g (yield 79%) of the title compound.

المصدر