تفاعل #9351

معادلة التفاعل

4-benzyloxyphenol

allylbromide

K2CO3

acetone

→

desired product

2,6-diallyl-4-benzyloxyphenol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was refluxed overnight
2. 2
   أخرىthe insoluble materials were removed by filtration
3. 3
   تركيزThe filtrate was concentrated in vac
4. 4
   أخرىThe residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL)
5. 5
   غسيلThe organic layer was washed with water and brine
6. 6
   تجفيفdried over anhydrous MgSO4
7. 7
   ترشيحfiltered
8. 8
   تركيزconcentrated in vac

الإجراء التجريبي

To a solution of starting 4-benzyloxyphenol (20 g) in acetone (800 mL) were added allylbromide (50 mL) and K2CO3 (60 g). The reaction mixture was refluxed overnight. After cooling to the room temperature, the insoluble materials were removed by filtration. The filtrate was concentrated in vac. The residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL). The organic layer was washed with water and brine, dried over anhydrous MgSO4, filtered, and concentrated in vac. to give the desired product.

المصدر