تفاعل #9349

معادلة التفاعل

CF3CH2SO2Cl

NH4OH

→

CF3CH2SO2NH2

المذيبات

water

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted three times with CH2Cl2
2. 2
   تجفيفThe combined organic layers were dried with Na2SO4
3. 3
   تركيزconcentrated
4. 4
   أخرىThe sulfonamide was used without further purification

الإجراء التجريبي

The CF3CH2SO2NH2 was prepared by cooling a solution of commercially available CF3CH2SO2Cl (0.6 ml, 1 eq) in CH2Cl2 to 0° C. NH4OH (0.75 ml, 14.8 N, 2 eq) was then added dropwise. The mixture was allowed to warm to room temperature overnight. The reaction was diluted with water and extracted three times with CH2Cl2. The combined organic layers were dried with Na2SO4 and concentrated. The sulfonamide was used without further purification.

المصدر