تفاعل #93367

معادلة التفاعل

2-methylbenzimidazole

triethylamine

4-(4-ethoxyphenoxy)benzyl chloride

→

1-[4-(4-ethoxyphenoxy)benzyl]-2-methylbenzimidazole

المردود 88.1%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 5 hours
3. 3
   غسيلThe resultant mixture was washed with water
4. 4
   تجفيفdried over anhydrous sodium sulfate
5. 5
   workup.DISTILLATIONdistilled under reduced pressure
6. 6
   أخرىto remove toluene
7. 7
   أخرىThe residue was purified by silica gel column chromatography

الإجراء التجريبي

A mixture of toluene (20 ml), 2-methylbenzimidazole (0.55 g, 4.2 mmole), triethylamine (0.42 g, 4.2 mmole) and 4-(4-ethoxyphenoxy)benzyl chloride (1.00 g, 3.8 mmole) was heated under reflux for 5 hours and then cooled to room temperature. The resultant mixture was washed with water, dried over anhydrous sodium sulfate and distilled under reduced pressure to remove toluene. The residue was purified by silica gel column chromatography to give 1-[4-(4-ethoxyphenoxy)benzyl]-2-methylbenzimidazole (1.20 g) as colorless liquid. nD26.0 1.5984.

المصدر