تفاعل #933077

ord-5a1ed69682d5438bb6eea563e91bc320

معادلة التفاعل

Cc1cc(O)cc(C)c1C[C@@H](C(=O)N[C@H](C)C(=O)[N-]CCCc1ccccc1)N(C)C(=O)OC(C)(C)C
N-methyl-BOC-2,6-dimethyltyrosyl-(D)-alanylphenylpropylamide
C1COCCO1.CO.Cl
methanol-HCl dioxane
→
CN[C@@H](Cc1c(C)cc(O)cc1C)C(=O)N[C@H](C)C(=O)NCCCc1ccccc1.Cl
N,2,6-trimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide, monohydrochloride

المتفاعلات

Cc1cc(O)cc(C)c1C[C@@H](C(=O)N[C@H](C)C(=O)[N-]CCCc1ccccc1)N(C)C(=O)OC(C)(C)C
N-methyl-BOC-2,6-dimethyltyrosyl-(D)-alanylphenylpropylamide
C1COCCO1.CO.Cl
methanol-HCl dioxane

الكواشف

لا شيء

المذيبات

CO
methanol

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىafter the removal of methanol-HCl/dioxane

الإجراء التجريبي

N-methyl-BOC-2,6-dimethyltyrosyl-(D)-alanylphenylpropylamide (iso F) from Example 12 was treated with methanol-HCl/dioxane as described in Example 12, except that no methanol was used after the removal of methanol-HCl/dioxane, so no reduction of volume was necessary before lyophilization. The product is

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04760180uspto-grants-1988_07