تفاعل #9320

معادلة التفاعل

ethyl acetate

m-Chloroperbenzoic acid

N,N-dicyclopropylmethyl-N-[7-(2-methoxy-4,6-dimethylphenyl)-2-(methylsulfinyl)pyrazolo[1,5-a]pyridin-3-yl]amine

Water

→

title compound

المردود 5.4%

N,N-Dicyclopropylmethyl-N-[7-(2-methoxy-4,6-dimethylphenyl)-2-(methylsulfonyl)pyrazolo[1,5-a]pyridin-3-yl]amine

المردود 5.4%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلthe extract was washed with saturated aqueous sodium hydrogencarbonate and brine
2. 2
   تجفيفdried over magnesium sulfate
3. 3
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

الإجراء التجريبي

m-Chloroperbenzoic acid (91 mg) was added to a solution of N,N-dicyclopropylmethyl-N-[7-(2-methoxy-4,6-dimethylphenyl)-2-(methylsulfinyl)pyrazolo[1,5-a]pyridin-3-yl]amine (162 mg) in dichloromethane (10 mL) at 0° C., and the mixture was stirred for 4 hours. Water was added to the reaction mixture, extraction was performed with ethyl acetate, the extract was washed with saturated aqueous sodium hydrogencarbonate and brine and dried over magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography (10 g), and the title compound (9 mg) was obtained from the n-hexane:ethyl acetate (1:2) fraction as a yellow oil.

المصدر