تفاعل #93138

معادلة التفاعل

2,6-dinitrobenzonitrile

piperidine

water

→

2-nitro-6-piperidinobenzonitrile

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile externally cooling because of heat generation
2. 2
   أخرىthe precipitate thus formed
3. 3
   أخرىwas collected
4. 4
   غسيلwashed with water
5. 5
   تجفيفwith methanol, and dried

الإجراء التجريبي

5.8 g of 2,6-dinitrobenzonitrile was dissolved in 30 ml of dimethylformamide, and 10.2 ml of piperidine was added to the solution. The mixture was stirred at 50° C. for 30 minutes while externally cooling because of heat generation. The reaction mixture was poured into water, and the precipitate thus formed was collected, washed with water and then with methanol, and dried to obtain 6.7 of 2-nitro-6-piperidinobenzonitrile (melting point: 122°-123° C.).

المصدر