تفاعل #931202

معادلة التفاعل

1,4-Dioxa-spiro[4.5]decane-8-carbonitrile

hydrochloric acid

→

oil

المردود 50.8%

4-Oxo-cyclohexanecarbonitrile

المردود 50.8%

المذيبات

ethyl acetate

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water and brine
2. 2
   تجفيفdried over MgSO4
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated to an oil which
5. 5
   أخرىwas purified via flash chromatography on silica using 10% ethyl acetate/hexane as eluent

الإجراء التجريبي

A solution of 1,4-Dioxa-spiro[4.5]decane-8-carbonitrile (2.0 grams, 12.8 mmole) and 2 N hydrochloric acid (21.0 grams, 42.0 mmole) in tetrahydrofuran (30 ml) at room temperature was stirred over night. The mixture was diluted with ethyl acetate, washed with water and brine, dried over MgSO4, filtered, and concentrated to an oil which was purified via flash chromatography on silica using 10% ethyl acetate/hexane as eluent to give an oil (0.800 g). MW 123.15.

المصدر